Publications

Klingler JH, Gizaw C, Blaß BI, Hohenhaus R, Neidert N, Neumann-Haefelin E, Kotsis F, Grauvogel J, Scheiwe C, Beck J. (2025) Intraoperative indocyanine green (ICG) videoangiography in spinal hemangioblastoma surgery - helpful tool or unnecessary? Clin Neurol Neurosurg, doi: 10.1016/j.clineuro.2024.108661.
Pal J, Riester M, Ganner A, Ghosh A, Dhamija S, Mookherjee D, Voss C, Frew IJ, Kotsis F, Neumann-Haefelin E, Spang A, Diederichs S. (2025) Nonstop mutations cause loss of renal tumor suppressor proteins VHL and BAP1 and affect multiple stages of protein translation Sci Adv, doi: 10.1126/sciadv.adr6375.
Feilen T, Rogg M, Andreev G, Pinter N, Wess M, Kössinger AL, Diel N, Neumann-Haefelin E, Ganner A, Grabbert M, Schell C, Schilling O. (2025) Proteomic characterization of the pseudocapsule of clear cell renal cell carcinoma in VHL disease reveals a distinct microenvironment at the tumor boundary zone. Neoplasia, doi: 10.1016/j.neo.2025.101214.
Pilz JF, Klein M, Neumann-Haefelin E, Ganner A. (2024) VHL-dependence of EHHADH Expression in a Human Renal Cell Carcinoma Cell Line. J Kidney Cancer VHL, doi: 10.15586/jkcvhl.v11i1.322.
Buckley M, Terwagne C, Ganner A, Cubitt L, Brewer R, Kim DK, Kajba CM, Forrester N, Dace P, De Jonghe J, Shepherd STC, Sawyer C, McEwen M, Diederichs S, Neumann-Haefelin E, Turajlic S, Ivakine EA, Findlay GM. (2024) Saturation genome editing maps the functional spectrum of pathogenic VHL alleles. Nat Genet, doi: 10.1038/s41588-024-01800-z.
Kotsis F, Kunstreich M, Redlich A, Rhein K, Ganner A, Walz G, Kuhlen M, Neumann-Haefelin E. (2024) Surveillance in Children and Adolescents with von Hippel-Lindau (VHL)-Related Pheochromocytomas and Paragangliomas: A Survey of MET and Freiburg-VHL Registries in Germany J Kidney Cancer VHL., doi: 10.15586/jkcvhl.v11i4.362.
Ganner A, Philipp A, Lagies S, Wingendorf L, Wang L, Pilz F, Welte T, Grand K, Lienkamp SS, Klein M, Kammerer B, Frew IJ, Walz G, Neumann-Haefelin E. (2023) SCD5 Regulation by VHL Affects Cell Proliferation and Lipid Homeostasis in ccRCC. Cells, doi: 10.3390/cells12060835.
Jaki L, Weigang S, Kern L, Kramme S, Wrobel AG, Grawitz AB, Nawrath P, Martin SR, Dähne T, Beer J, Disch M, Kolb P, Gutbrod L, Reuter S, Warnatz K, Schwemmle M, Gamblin SJ, Neumann-Haefelin E, Schnepf D, Welte T, Kochs G, Huzly D, Panning M, Fuchs J. (2023) Total escape of SARS-CoV-2 from dual monoclonal antibody therapy in an immunocompromised patient. Nat Commun, doi: 10.1038/s41467-023-37591-w.
Welte T, Arnold F, Westermann L, Rottmann FA, Hug MJ, Neumann-Haefelin E, Ganner A. (2023) Eculizumab as a treatment for C3 glomerulopathy: a single-center retrospective study. BMC Nephrol, doi: 10.1186/s12882-023-03058-9.
Mohl DA, Lagies S, Zodel K, Zumkeller M, Peighambari A, Ganner A, Plattner DA, Neumann-Haefelin E, Adlesic M, Frew IJ, Kammerer B. (2023) Integrated Metabolomic and Transcriptomic Analysis of Modified Nucleosides for Biomarker Discovery in Clear Cell Renal Cell Carcinoma. Cells, doi: 10.3390/cells12081102.
Kirste S, Rühle A, Zschiedrich S, Schultze-Seemann W, Jilg CA, Neumann-Haefelin E, Lo SS, Grosu AL, Kim E. (2022) Stereotactic Body Radiotherapy for Renal Cell Carcinoma in Patients with Von Hippel-Lindau Disease-Results of a Prospective Trial. Cancers (Basel), doi: 10.3390/cancers14205069.
Schneider J, Walz G, Neumann-Haefelin E. (2021) Hypertensive Erkrankungen in der Schwangerschaft [Hypertensive Disorders in Pregnancy] Dtsch Med Wochenschr, doi: 10.1055/a-1233-7685. [Article in German]
Reich M, Jaegle S, Neumann-Haefelin E, Klingler JH, Evers C, Daniel M, Bucher F, Ludwig F, Nuessle S, Kopp J, Boehringer D, Reinhard T, Lagrèze WA, Lange C, Agostini H, Lang SJ. (2021) Genotype-phenotype correlation in von Hippel-Lindau disease Acta Ophthalmol, doi: 10.1111/aos.14843.
Kotsis F, Janusch H, Li Y, Viau A, Epting D, Kramer-Zucker A, Walz G, Nitschke R, Lorentzen E, Ganner A, Neumann-Haefelin E, Kuehn EW, Boehlke C. (2021) Ift88, but not Kif3a, is required for establishment of the periciliary membrane compartment. Biochem Biophys Res Commun, doi: 10.1016/j.bbrc.2021.10.075.
Ganner A, Pfeiffer ZC, Wingendorf L, Kreis S, Klein M, Walz G and Neumann-Haefelin E. (2020) The acetyltransferase p300 regulates NRF2 stability and localization Biochem Biophys Res Commun, doi: 10.1016/j.bbrc.2020.02.006.
Arnold F, Westermann L, Rieg S, Neumann-Haefelin E, Biever PM, Walz G, Kalbhenn J, Tanriver Y. (2020) Comparison of different anticoagulation strategies for renal replacement therapy in critically ill patients with COVID-19: a cohort study. BMC Nephrol, doi: 10.1186/s12882-020-02150-8.
Neumann-Haefelin E, Widmeier E, Bansbach J, Kaufmann K, Heinrich S, Walz G, Bürkle H, and Kalbhenn J. (2020) Subcutaneous Enoxaparin Safely Facilitates Bedside Sustained Low-Efficiency Hemodialysis in Hypercoagulopathic Coronavirus Disease 2019 Patients—A Proof-of-Principle Trial Crit Care Explor, doi: 10.1097/CCE.0000000000000155
Klingler JH, Gläsker S, Bausch B, Urbach H, Krauss T, Jilg CA, Steiert C, Puzik A, Neumann-Haefelin E, Kotsis F, Agostini H, Neumann HPH, and Beck J. (2020) Hemangioblastoma and von Hippel-Lindau disease: genetic background, spectrum of disease, and neurosurgical treatment Childs Nerv Syst, doi: 10.1007/s00381-020-04712-5
Ganner A, Gerber J, Ziegler AK, Li Y, Kandzia J, Matulenski T, Kreis S, Breves G, Klein M, Walz G and Neumann-Haefelin E. (2019) CBP-1/p300 acetyltransferase regulates SKN-1/Nrf cellular levels, nuclear localization, and activity in C. elegans Exp Gerontol, doi: 10.1016/j.exger.2019.110690.
Bechtel-Walz W, Walz G and Neumann-Haefelin E. (2019) Long-Term Therapeutic Plasma Exchange Therapy as Effective Approach to Refractory Primary Acquired Pregnancy-Related Thrombocytopenic Purpura Ther Apher Dial, doi: 10.1111/1744-9987.12748.
Li Y, Finkbeiner S, Ganner A, Gerber J, Klein M, Grafe M, Kandzia J, Thien A, Thedieck K, Breves G, Jank T, Baumeister R, Walz G and Neumann-Haefelin E. (2018) CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegans Oncotarget, doi: 10.18632/oncotarget.24039.
Welte T, Arnold F, Kappes J, Seidl M, Häffner K, Bergmann C, Walz G and Neumann-Haefelin E. (2018) Treating C3 glomerulopathy with eculizumab BMC Nephrol, doi: 10.1186/s12882-017-0802-4.
Rassner MP, Seidl M, Salzer U, Rajkumar SV, Epting T, Wäsch R, Neumann-Haefelin E and Engelhardt M. (2018) Cast Nephropathy and Deceptively Low Absolute Serum Free Light Chain Levels: Resolution of a Challenging Case and Systematic Review of the Literature Clin Lymphoma Myeloma Leuk, doi: 10.1016/j.clml.2017.09.019.
Ganner A and Neumann-Haefelin E. (2017) Genetic kidney diseases: Caenorhabditis elegans as model system Cell Tissue Res, doi: 10.1007/s00441-017-2622-z.
Dottermusch M, Lakner T, Peyman T, Klein M, Walz G and Neumann-Haefelin E. (2016) Cell cycle controls stress response and longevity in C. elegans Aging (Albany NY), doi: 10.18632/aging.101052.
Welte T, Arnold F, Technau-Hafsi K, Neumann-Haefelin E, Wobser R, Zschiedrich S, Walz G and Kramer-Zucker A. (2016) Successful Management of Calciphylaxis in a Kidney Transplant Patient: Case Report Transplant Direct, doi: 10.1097/TXD.0000000000000582.
A. Thien, M. T. Prentzell, B. Holzwarth, K. Klasener, I. Kuper, C. Boehlke, A. G. Sonntag, S. Ruf, L. Maerz, R. Nitschke, S. N. Grellscheid, M. Reth, G. Walz, R. Baumeister, E. Neumann-Haefelin and K. Thedieck (2015) TSC1 Activates TGF-beta-Smad2/3 Signaling in Growth Arrest and Epithelial-to-Mesenchymal Transition Dev Cell 32, 617-30
A. Dresen, S. Finkbeiner, M. Dottermusch, J. S. Beume, Y. Li, G. Walz and E. Neumann-Haefelin (2015) Caenorhabditis elegans OSM-11 signaling regulates SKN-1/Nrf during embryonic development and adult longevity and stress response Dev Biol 400, 118-31
M. Mizunuma, E. Neumann-Haefelin, N. Moroz, Y. Li and T. K. Blackwell (2014) mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity Aging Cell 13, 869-78
C. Boehlke, B. Hartleben, T. B. Huber, H. Hopfer, G. Walz and E. Neumann-Haefelin (2014) Hantavirus infection with severe proteinuria and podocyte foot-process effacement Am J Kidney Dis 64, 452-456
V. Ruf, C. Holzem, T. Peyman, G. Walz, T. K. Blackwell and E. Neumann-Haefelin (2013) TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development Dev Biol 384, 214-27.
W. Qi, X. Huang, E. Neumann-Haefelin, E. Schulze and R. Baumeister (2012) Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegans PLoS Genet 8, e1002836.
S. Robida-Stubbs, K. Glover-Cutter, D. W. Lamming, M. Mizunuma, S. D. Narasimhan, E. Neumann-Haefelin, D. M. Sabatini and T. K. Blackwell (2012) TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO Cell Metab 15, 713-24.
P. Dalle Pezze, A. G. Sonntag, A. Thien, M. T. Prentzell, M. Godel, S. Fischer, E. Neumann-Haefelin, T. B. Huber, R. Baumeister, D. P. Shanley and K. Thedieck (2012) A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation Sci Signal 5, ra25.
N. Wanner, F. Noutsou, R. Baumeister, G. Walz, T. B. Huber and E. Neumann-Haefelin (2011) Functional and spatial analysis of C. elegans SYG-1 and SYG-2, orthologs of the Neph/nephrin cell adhesion module directing selective synaptogenesis PLoS One 6, e23598.
M. Hohne, J. Lorscheider, A. von Bardeleben, M. Dufner, M. A. Scharf, M. Godel, M. Helmstadter, E. M. Schurek, S. Zank, P. Gerke, C. Kurschat, S. H. Sivritas, E. Neumann-Haefelin, T. B. Huber, H. C. Reinhardt, A. C. Schauss, B. Schermer, K. F. Fischbach and T. Benzing (2011) The BAR domain protein PICK1 regulates cell recognition and morphogenesis by interacting with Neph proteins Mol Cell Biol 31, 3241-51.
J. Wilpert, K. G. Fischer, P. Pisarski, T. Wiech, M. Daskalakis, A. Ziegler, E. Neumann-Haefelin, O. Drognitz, F. Emmerich, G. Walz and M. Geyer (2010) Long-term outcome of ABO-incompatible living donor kidney transplantation based on antigen-specific desensitization. An observational comparative analysis Nephrol Dial Transplant 25, 3778-86.
E. Neumann-Haefelin, A. Kramer-Zucker, K. Slanchev, B. Hartleben, F. Noutsou, K. Martin, N. Wanner, A. Ritter, M. Godel, P. Pagel, X. Fu, A. Muller, R. Baumeister, G. Walz and T. B. Huber (2010) A model organism approach: defining the role of Neph proteins as regulators of neuron and kidney morphogenesis Hum Mol Genet 19, 2347-59.
E. Neumann-Haefelin, W. Qi, E. Finkbeiner, G. Walz, R. Baumeister and M. Hertweck (2008) SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans Genes Dev 22, 2721-35.
B. Hartleben, H. Schweizer, P. Lubben, M. P. Bartram, C. C. Moller, R. Herr, C. Wei, E. Neumann-Haefelin, B. Schermer, H. Zentgraf, D. Kerjaschki, J. Reiser, G. Walz, T. Benzing and T. B. Huber (2008) Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity J Biol Chem 283, 23033-8.
R. Baumeister, E. Schaffitzel and M. Hertweck (2006) Endocrine signaling in Caenorhabditis elegans controls stress response and longevity J Endocrinol 190, 191-202.
A. Nebel, E. Schaffitzel and M. Hertweck (2006) Aging at the interface of stem cell renewal, apoptosis, senescence, and cancer Sci Aging Knowledge Environ 2006, pe14.
E. Schaffitzel and M. Hertweck (2006) Recent aging research in Caenorhabditis elegans Exp Gerontol 41, 557-63.
E. Deuerling, H. Patzelt, S. Vorderwulbecke, T. Rauch, G. Kramer, E. Schaffitzel, A. Mogk, A. Schulze-Specking, H. Langen and B. Bukau (2003) Trigger Factor and DnaK possess overlapping substrate pools and binding specificities Mol Microbiol 47, 1317-28.
H. Patzelt, S. Rudiger, D. Brehmer, G. Kramer, S. Vorderwulbecke, E. Schaffitzel, A. Waitz, T. Hesterkamp, L. Dong, J. Schneider-Mergener, B. Bukau and E. Deuerling (2001) Binding specificity of Escherichia coli trigger factor Proc Natl Acad Sci U S A 98, 14244-9.
E. Schaffitzel, S. Rudiger, B. Bukau and E. Deuerling (2001) Functional dissection of trigger factor and DnaK: interactions with nascent polypeptides and thermally denatured proteins Biol Chem 382, 1235-43.
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