Publications

S. Lienkamp; A. Ganner; G. Walz (2011) Inversin, Wnt signaling and primary cilia Differentiation.
R. N. Rashmi; B. Eckes; G. Glockner; M. Groth; S. Neumann; J. Gloy; L. Sellin; G. Walz; M. Schneider; I. Karakesisoglou; L. Eichinger; A. A. Noegel (2011) The nuclear envelope protein Nesprin-2 has roles in cell proliferation and differentiation during wound healing Nucleus 3.
K. U. Eckardt; B. Barthlein; S. Baid-Agrawal; A. Beck; M. Busch; F. Eitner; A. B. Ekici; J. Floege; O. Gefeller; H. Haller; R. Hilge; K. F. Hilgers; J. T. Kielstein; V. Krane; A. Kottgen; F. Kronenberg; P. Oefner; H. U. Prokosch; A. Reis; M. Schmid; E. Schaeffner; U. T. Schultheiss; S. A. Seuchter; T. Sitter; C. Sommerer; G. Walz; C. Wanner; G. Wolf; M. Zeier; S. Titze (2011) The German Chronic Kidney Disease (GCKD) study: design and methods Nephrol Dial Transplant.
N. Wanner; F. Noutsou; R. Baumeister; G. Walz; T. B. Huber; E. Neumann-Haefelin (2011) Functional and spatial analysis of C. elegans SYG-1 and SYG-2, orthologs of the Neph/nephrin cell adhesion module directing selective synaptogenesis PLoS One 6, e23598.
M. Godel; B. Hartleben; N. Herbach; S. Liu; S. Zschiedrich; S. Lu; A. Debreczeni-Mor; M. T. Lindenmeyer; M. P. Rastaldi; G. Hartleben; T. Wiech; A. Fornoni; R. G. Nelson; M. Kretzler; R. Wanke; H. Pavenstadt; D. Kerjaschki; C. D. Cohen; M. N. Hall; M. A. Ruegg; K. Inoki; G. Walz; T. B. Huber (2011) Role of mTOR in podocyte function and diabetic nephropathy in humans and mice J Clin Invest 121, 2197-209.
K. Slanchev; M. Putz; A. Schmitt; A. Kramer-Zucker; G. Walz (2011) Nephrocystin-4 is required for pronephric duct-dependent cloaca formation in zebrafish Hum Mol Genet 20, 3119-28.
M. C. Liebau; K. Hopker; R. U. Muller; I. Schmedding; S. Zank; B. Schairer; F. Fabretti; M. Hohne; M. P. Bartram; C. Dafinger; M. Hackl; V. Burst; S. Habbig; H. Zentgraf; A. Blaukat; G. Walz; T. Benzing; B. Schermer (2011) Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of Nephrocystin-1 to control targeting to monocilia J Biol Chem.
T. B. Huber; G. Walz; E. W. Kuehn (2011) mTOR and rapamycin in the kidney: signaling and therapeutic implications beyond immunosuppression Kidney Int 79, 502-11.
M. Geyer; J. Wilpert; T. Wiech; C. Theilacker; M. Stubanus; A. Kramer-Zucker; K. G. Fischer; O. Drognitz; A. Frydrychowicz; W. Kern; G. Walz; P. Pisarski (2011) Rapidly progressive hepatic alveolar echinococcosis in an ABO-incompatible renal transplant recipient Transpl Infect Dis 13, 278-84.
G. Walz; K. Budde; K. U. Eckardt (2011) mTOR inhibitors and autosomal dominant polycystic kidney disease (authors reply) N Engl J Med 364, 287-288.
S. Lienkamp; A. Ganner; C. Boehlke; T. Schmidt; S. J. Arnold; T. Schafer; D. Romaker; J. Schuler; S. Hoff; C. Powelske; A. Eifler; C. Kronig; A. Bullerkotte; R. Nitschke; E. W. Kuehn; E. Kim; H. Burkhardt; T. Brox; O. Ronneberger; J. Gloy; G. Walz (2010) Inversin relays Frizzled-8 signals to promote proximal pronephros development Proc Natl Acad Sci U S A 107, 20388-93.
M. Geyer; J. Wilpert; T. Wiech; C. Theilacker; M. Stubanus; A. Kramer-Zucker; K. G. Fischer; O. Drognitz; A. Frydrychowicz; W. Kern; G. Walz; P. Pisarski (2010) Rapidly progressive hepatic alveolar echinococcosis in an ABO-incompatible renal transplant recipient Transpl Infect Dis.
C. Boehlke; F. Kotsis; V. Patel; S. Braeg; H. Voelker; S. Bredt; T. Beyer; H. Janusch; C. Hamann; M. Godel; K. Muller; M. Herbst; M. Hornung; M. Doerken; M. Kottgen; R. Nitschke; P. Igarashi; G. Walz; E. W. Kuehn (2010) Primary cilia regulate mTORC1 activity and cell size through Lkb1 Nat Cell Biol 12, 1115-22.
G. Walz; K. Budde; M. Mannaa; J. Nurnberger; C. Wanner; C. Sommerer; U. Kunzendorf; B. Banas; W. H. Horl; N. Obermuller; W. Arns; H. Pavenstadt; J. Gaedeke; M. Buchert; C. May; H. Gschaidmeier; S. Kramer; K. U. Eckardt (2010) Everolimus in patients with autosomal dominant polycystic kidney disease N Engl J Med 363, 830-40.
T. Hermle; D. Saltukoglu; J. Grunewald; G. Walz; M. Simons (2010) Regulation of Frizzled-dependent planar polarity signaling by a V-ATPase subunit Curr Biol 20, 1269-76.
J. Wilpert; K. G. Fischer; P. Pisarski; T. Wiech; M. Daskalakis; A. Ziegler; E. Neumann-Haefelin; O. Drognitz; F. Emmerich; G. Walz; M. Geyer (2010) Long-term outcome of ABO-incompatible living donor kidney transplantation based on antigen-specific desensitization. An observational comparative analysis Nephrol Dial Transplant 25, 3778-86.
C. Boehlke; M. Bashkurov; A. Buescher; T. Krick; A. K. John; R. Nitschke; G. Walz; E. W. Kuehn (2010) Differential role of Rab proteins in ciliary trafficking: Rab23 regulates smoothened levels J Cell Sci 123, 1460-7.
E. Neumann-Haefelin; A. Kramer-Zucker; K. Slanchev; B. Hartleben; F. Noutsou; K. Martin; N. Wanner; A. Ritter; M. Godel; P. Pagel; X. Fu; A. Muller; R. Baumeister; G. Walz; T. B. Huber (2010) A model organism approach: defining the role of Neph proteins as regulators of neuron and kidney morphogenesis Hum Mol Genet 19, 2347-59.
M. Gerner; R. Haribaskar; M. Putz; J. Czerwitzki; G. Walz; T. Schafer (2010) The retinitis pigmentosa GTPase regulator interacting protein 1 (RPGRIP1) links RPGR to the nephronophthisis protein network Kidney Int 77, 891-6.
B. Hartleben; M. Godel; C. Meyer-Schwesinger; S. Liu; T. Ulrich; S. Kobler; T. Wiech; F. Grahammer; S. J. Arnold; M. T. Lindenmeyer; C. D. Cohen; H. Pavenstadt; D. Kerjaschki; N. Mizushima; A. S. Shaw; G. Walz; T. B. Huber (2010) Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice J Clin Invest 120, 1084-96.
H. Peng; U. Lewandrowski; B. Muller; A. Sickmann; G. Walz; T. Wegierski (2010) Identification of a Protein Kinase C-dependent phosphorylation site involved in sensitization of TRPV4 channel Biochem Biophys Res Commun 391, 1721-5.
G. Walz; E. Kim (2010) Wnt signaling and rejuvenation of the adult kidney Nephrol Dial Transplant 25, 34-6.
H. Gao; Y. Wang; T. Wegierski; K. Skouloudaki; M. Putz; X. Fu; C. Engel; C. Boehlke; H. Peng; E. W. Kuehn; E. Kim; A. Kramer-Zucker; G. Walz (2010) PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation Hum Mol Genet 19, 16-24.
A. Ganner; S. Lienkamp; T. Schafer; D. Romaker; T. Wegierski; T. J. Park; S. Spreitzer; M. Simons; J. Gloy; E. Kim; J. B. Wallingford; G. Walz (2009) Regulation of ciliary polarity by the APC/C Proc Natl Acad Sci U S A 106, 17799-804.
S. Teschner; P. Gerke; M. Geyer; J. Wilpert; B. Krumme; T. Benzing; G. Walz (2009) Leflunomide therapy for polyomavirus-induced allograft nephropathy: efficient BK virus elimination without increased risk of rejection Transplant Proc 41, 2533-8.
R. Haribaskar; M. Putz; B. Schupp; K. Skouloudaki; A. Bietenbeck; G. Walz; T. Schafer (2009) The planar cell polarity (PCP) protein Diversin translocates to the nucleus to interact with the transcription factor AF9 Biochem Biophys Res Commun 387, 212-7.
K. Skouloudaki; M. Puetz; M. Simons; J. R. Courbard; C. Boehlke; B. Hartleben; C. Engel; M. J. Moeller; C. Englert; F. Bollig; T. Schafer; H. Ramachandran; M. Mlodzik; T. B. Huber; E. W. Kuehn; E. Kim; A. Kramer-Zucker; G. Walz (2009) Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development Proc Natl Acad Sci U S A 106, 8579-84.
H. Gao; L. K. Sellin; M. Putz; C. Nickel; M. Imgrund; P. Gerke; R. Nitschke; G. Walz; A. G. Kramer-Zucker (2009) A short carboxy-terminal domain of polycystin-1 reorganizes the microtubular network and the endoplasmic reticulum Exp Cell Res 315, 1157-70.
T. B. Huber; B. Hartleben; K. Winkelmann; L. Schneider; J. U. Becker; M. Leitges; G. Walz; H. Haller; M. Schiffer (2009) Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome J Am Soc Nephrol 20, 798-806.
R. Wobser; J. Wilpert; G. Kayser; G. Walz; M. Stubanus (2009) [Disseminated histoplasmosis with involvement of mediastinum and skin in an immunocompetent patient] Dtsch Med Wochenschr 134, 589-93.
B. Rumberger; C. Kreutz; C. Nickel; M. Klein; S. Lagoutte; S. Teschner; J. Timmer; P. Gerke; G. Walz; J. Donauer (2009) Combination of immunosuppressive drugs leaves specific "fingerprint" on gene expression in vitro Immunopharmacol Immunotoxicol 31, 283-92.
T. Wegierski; D. Steffl; C. Kopp; R. Tauber; B. Buchholz; R. Nitschke; E. W. Kuehn; G. Walz; M. Kottgen (2009) TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum EMBO J 28, 490-9.
W. Reichardt; D. Romaker; A. Becker; M. Buechert; G. Walz; D. von Elverfeldt (2009) Monitoring kidney and renal cyst volumes applying MR approaches on a rapamycin treated mouse model of ADPKD MAGMA 22, 143-9.
T. Wegierski; U. Lewandrowski; B. Muller; A. Sickmann; G. Walz (2009) Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli J Biol Chem 284, 2923-33.
M. Geyer; K. G. Fischer; O. Drognitz; G. Walz; P. Pisarski; J. Wilpert (2009) ABO-incompatible kidney transplantation with antigen-specific immunoadsorption and rituximab - insights and uncertainties Contrib Nephrol 162, 47-60.
D. Romaker; M. Puetz; S. Teschner; J. Donauer; M. Geyer; P. Gerke; B. Rumberger; B. Dworniczak; P. Pennekamp; B. Buchholz; H. P. Neumann; R. Kumar; J. Gloy; K. U. Eckardt; G. Walz (2009) Increased expression of secreted frizzled-related protein 4 in polycystic kidneys J Am Soc Nephrol 20, 48-56.
E. Neumann-Haefelin; W. Qi; E. Finkbeiner; G. Walz; R. Baumeister; M. Hertweck (2008) SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans Genes Dev 22, 2721-35.
T. Schafer; M. Putz; S. Lienkamp; A. Ganner; A. Bergbreiter; H. Ramachandran; V. Gieloff; M. Gerner; C. Mattonet; P. G. Czarnecki; J. A. Sayer; E. A. Otto; F. Hildebrandt; A. Kramer-Zucker; G. Walz (2008) Genetic and physical interaction between the NPHP5 and NPHP6 gene products Hum Mol Genet 17, 3655-62.
M. Kottgen; B. Buchholz; M. A. Garcia-Gonzalez; F. Kotsis; X. Fu; M. Doerken; C. Boehlke; D. Steffl; R. Tauber; T. Wegierski; R. Nitschke; M. Suzuki; A. Kramer-Zucker; G. G. Germino; T. Watnick; J. Prenen; B. Nilius; E. W. Kuehn; G. Walz (2008) TRPP2 and TRPV4 form a polymodal sensory channel complex J Cell Biol 182, 437-47.
B. Hartleben; H. Schweizer; P. Lubben; M. P. Bartram; C. C. Moller; R. Herr; C. Wei; E. Neumann-Haefelin; B. Schermer; H. Zentgraf; D. Kerjaschki; J. Reiser; G. Walz; T. Benzing; T. B. Huber (2008) Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity J Biol Chem 283, 23033-8.
Y. Luke; H. Zaim; I. Karakesisoglou; V. M. Jaeger; L. Sellin; W. Lu; M. Schneider; S. Neumann; A. Beijer; M. Munck; V. C. Padmakumar; J. Gloy; G. Walz; A. A. Noegel (2008) Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin J Cell Sci 121, 1887-98.
F. Kotsis; R. Nitschke; M. Doerken; G. Walz; E. W. Kuehn (2008) Flow modulates centriole movements in tubular epithelial cells Pflugers Arch 456, 1025-35.
X. Fu; Y. Wang; N. Schetle; H. Gao; M. Putz; G. von Gersdorff; G. Walz; A. G. Kramer-Zucker (2008) The subcellular localization of TRPP2 modulates its function J Am Soc Nephrol 19, 1342-51.
C. Bergmann; M. Fliegauf; N. O. Bruchle; V. Frank; H. Olbrich; J. Kirschner; B. Schermer; I. Schmedding; A. Kispert; B. Kranzlin; G. Nurnberg; C. Becker; T. Grimm; G. Girschick; S. A. Lynch; P. Kelehan; J. Senderek; T. J. Neuhaus; T. Stallmach; H. Zentgraf; P. Nurnberg; N. Gretz; C. Lo; S. Lienkamp; T. Schafer; G. Walz; T. Benzing; K. Zerres; H. Omran (2008) Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia Am J Hum Genet 82, 959-70.
T. Benzing; G. Walz (2008) Pathogenesis of nephronophthisis and medullary cystic kidney disease. Molecular and genetic basis of renal disease (edited by D. B. Mount and M. R. Pollak) Philadelphia: Saunders Elsevier.
T. Benzing; G. Walz (2008)
E. W. Kuehn; M. N. Hirt; A. K. John; P. Muehlenhardt; C. Boehlke; M. Putz; A. G. Kramer-Zucker; M. Bashkurov; P. S. van de Weyer; F. Kotsis; G. Walz (2007) Kidney injury molecule 1 (Kim1) is a novel ciliary molecule and interactor of polycystin 2 Biochem Biophys Res Commun 364, 861-6.
M. Geyer; J. Donauer; P. Pisarski; O. Drognitz; C. Schulz-Huotari; U. Wisniewski; A. Gropp; H. Gobel; P. Gerke; S. Teschner; G. Walz; J. Wilpert (2007) Preemptive postoperative antigen-specific immunoadsorption in ABO-incompatible kidney transplantation: necessary or not? Transplantation 84, S40-3.
J. Wilpert; M. Geyer; S. Teschner; T. Schaefer; P. Pisarski; C. Schulz-Huotari; A. Gropp; U. Wisniewski; H. Goebel; P. Gerke; G. Walz; J. Donauer (2007) ABO-incompatible kidney transplantation-proposal of an intensified apheresis strategy for patients with high initial isoagglutinine titers J Clin Apher 22, 314-22.
E. Kim; G. Walz (2007) Sensitive cilia set up the kidney Nat Med 13, 1409-11.
U. T. Schultheiss; H. Gobel; G. von Gersdorff; M. Stubanus; G. Walz; P. Gerke (2007) Quiz page December 2007: diarrhea and anuria in a recipient of an en bloc infant kidney transplant Am J Kidney Dis 50, A41-3.
S. Clorius; K. Technau; T. Watter; E. Schwertfeger; K. G. Fischer; G. Walz; P. Gerke (2007) Nephrogenic systemic fibrosis following exposure to gadolinium-containing contrast agent Clin Nephrol 68, 249-52.
Y. Wang; X. Fu; S. Gaiser; M. Kottgen; A. Kramer-Zucker; G. Walz; T. Wegierski (2007) OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum J Biol Chem 282, 36561-70.
B. Rumberger; O. Vonend; C. Kreutz; J. Wilpert; J. Donauer; K. Amann; R. Rohrbach; J. Timmer; G. Walz; P. Gerke (2007) cDNA microarray analysis of adaptive changes after renal ablation in a sclerosis-resistant mouse strain Kidney Blood Press Res 30, 377-87.
A. Ganner; Y. M. Lee; C. Busche; A. Schmitt-Graeff; J. Encke; G. Walz; P. Gerke (2007) Successful liver transplantation in a kidney and pancreas allograft recipient with fulminant herpes simplex virus type 2 hepatitis Nephrol Dial Transplant 22, 3334-7.
D. Steffl; H. Gobel; C. Groth; K. G. Fischer; W. Kuhn; G. Walz; P. Gerke (2007) Quiz page. Renal AA amyloidosis with vascular predominance, secondary to rheumatoid arthritis Am J Kidney Dis 49, A49-50.
M. Stubanus; H. Gobel; S. Rieg; G. Walz; P. Gerke (2007) Quiz page. Minimal change glomerulonephritis associated with secondary syphilis Am J Kidney Dis 49, A49-50.
J. Wilpert; M. Geyer; P. Pisarski; O. Drognitz; C. Schulz-Huotari; A. Gropp; H. Goebel; P. Gerke; S. Teschner; G. Walz; J. Donauer (2007) On-demand strategy as an alternative to conventionally scheduled post-transplant immunoadsorptions after ABO-incompatible kidney transplantation Nephrol Dial Transplant 22, 3048-51.
E. W. Kuehn; G. Walz; T. Benzing (2007) Von hippel-lindau: a tumor suppressor links microtubules to ciliogenesis and cancer development Cancer Res 67, 4537-40.
T. Benzing; M. Simons; G. Walz (2007) Wnt signaling in polycystic kidney disease J Am Soc Nephrol 18, 1389-98.
E. W. Kuehn; G. Walz (2007) Prime time for polycystic kidney disease: does one shot of roscovitine bring the cure? Nephrol Dial Transplant 22, 2133-5.
F. Kotsis; R. Nitschke; C. Boehlke; M. Bashkurov; G. Walz; E. W. Kuehn (2007) Ciliary calcium signaling is modulated by kidney injury molecule-1 (Kim1) Pflugers Arch 453, 819-29.
T. Wegierski; K. Hill; M. Schaefer; G. Walz (2006) The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels EMBO J 25, 5659-69.
B. Schermer; C. Ghenoiu; M. Bartram; R. U. Muller; F. Kotsis; M. Hohne; W. Kuhn; M. Rapka; R. Nitschke; H. Zentgraf; M. Fliegauf; H. Omran; G. Walz; T. Benzing (2006) The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth J Cell Biol 175, 547-54.
T. B. Huber; B. Schermer; R. U. Muller; M. Hohne; M. Bartram; A. Calixto; H. Hagmann; C. Reinhardt; F. Koos; K. Kunzelmann; E. Shirokova; D. Krautwurst; C. Harteneck; M. Simons; H. Pavenstadt; D. Kerjaschki; C. Thiele; G. Walz; M. Chalfie; T. Benzing (2006) Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels Proc Natl Acad Sci U S A 103, 17079-86.
P. S. van de Weyer; M. Muehlfeit; C. Klose; J. V. Bonventre; G. Walz; E. W. Kuehn (2006) A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9 Biochem Biophys Res Commun 351, 571-6.
P. Gerke; T. Benzing; M. Hohne; A. Kispert; M. Frotscher; G. Walz; O. Kretz (2006) Neuronal expression and interaction with the synaptic protein CASK suggest a role for Neph1 and Neph2 in synaptogenesis J Comp Neurol 498, 466-75.
M. Simons; G. Walz (2006) Polycystic kidney disease: cell division without a c(l)ue? Kidney Int 70, 854-64.
X. Fang; M. B. Zeisel; J. Wilpert; B. Gissler; R. Thimme; C. Kreutz; T. Maiwald; J. Timmer; W. V. Kern; J. Donauer; M. Geyer; G. Walz; E. Depla; F. von Weizsacker; H. E. Blum; T. F. Baumert (2006) Host cell responses induced by hepatitis C virus binding Hepatology 43, 1326-36.
G. Walz (2006) Therapeutic approaches in autosomal dominant polycystic kidney disease (ADPKD): is there light at the end of the tunnel? Nephrol Dial Transplant 21, 1752-7.
J. A. Sayer; E. A. Otto; J. F. O'Toole; G. Nurnberg; M. A. Kennedy; C. Becker; H. C. Hennies; J. Helou; M. Attanasio; B. V. Fausett; B. Utsch; H. Khanna; Y. Liu; I. Drummond; I. Kawakami; T. Kusakabe; M. Tsuda; L. Ma; H. Lee; R. G. Larson; S. J. Allen; C. J. Wilkinson; E. A. Nigg; C. Shou; C. Lillo; D. S. Williams; B. Hoppe; M. J. Kemper; T. Neuhaus; M. A. Parisi; I. A. Glass; M. Petry; A. Kispert; J. Gloy; A. Ganner; G. Walz; X. Zhu; D. Goldman; P. Nurnberg; A. Swaroop; M. R. Leroux; F. Hildebrandt (2006) The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4 Nat Genet 38, 674-81.
S. Teschner; M. Geyer; J. Wilpert; E. Schwertfeger; T. Schenk; G. Walz; J. Donauer (2006) Remission of polyomavirus-induced graft nephropathy treated with low-dose leflunomide Nephrol Dial Transplant 21, 2039-40.
J. Donauer; J. Wilpert; M. Geyer; E. Schwertfeger; G. Kirste; O. Drognitz; G. Walz; P. Pisarski (2006) ABO-incompatible kidney transplantation using antigen-specific immunoadsorption and rituximab: a single center experience Xenotransplantation 13, 108-10.
T. Benzing; G. Walz (2006) Cilium-generated signaling: a cellular GPS? Curr Opin Nephrol Hypertens 15, 245-9.
J. M. Shillingford; N. S. Murcia; C. H. Larson; S. H. Low; R. Hedgepeth; N. Brown; C. A. Flask; A. C. Novick; D. A. Goldfarb; A. Kramer-Zucker; G. Walz; K. B. Piontek; G. G. Germino; T. Weimbs (2006) The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease Proc Natl Acad Sci U S A 103, 5466-71.
G. Schieren; B. Rumberger; M. Klein; C. Kreutz; J. Wilpert; M. Geyer; D. Faller; J. Timmer; I. Quack; L. C. Rump; G. Walz; J. Donauer (2006) Gene profiling of polycystic kidneys Nephrol Dial Transplant 21, 1816-24.
M. Horndasch; S. Lienkamp; E. Springer; A. Schmitt; H. Pavenstadt; G. Walz; J. Gloy (2006) The C/EBP homologous protein CHOP (GADD153) is an inhibitor of Wnt/TCF signals Oncogene 25, 3397-407.
G. Walz (2006) Cell and molecular biology in medicine: Basic science and clinical relevance in the example of autosomal polycystic kidney diseases. Fortschritte in der Inneren Medizin.
B. Schermer; K. Hopker; H. Omran; C. Ghenoiu; M. Fliegauf; A. Fekete; J. Horvath; M. Kottgen; M. Hackl; S. Zschiedrich; T. B. Huber; A. Kramer-Zucker; H. Zentgraf; A. Blaukat; G. Walz; T. Benzing (2005) Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia EMBO J 24, 4415-24.
G. Walz (2005) Slit or pore? A mutation of the ion channel TRPC6 causes FSGS Nephrol Dial Transplant 20, 1777-9.
M. Kottgen; G. Walz (2005) Subcellular localization and trafficking of polycystins Pflugers Arch 451, 286-93.
M. Simons; J. Gloy; A. Ganner; A. Bullerkotte; M. Bashkurov; C. Kronig; B. Schermer; T. Benzing; O. A. Cabello; A. Jenny; M. Mlodzik; B. Polok; W. Driever; T. Obara; G. Walz (2005) Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways Nat Genet 37, 537-43.
P. Gerke; L. Sellin; O. Kretz; D. Petraschka; H. Zentgraf; T. Benzing; G. Walz (2005) NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases J Am Soc Nephrol 16, 1693-702.
P. S. Goerttler; C. Kreutz; J. Donauer; D. Faller; T. Maiwald; E. Marz; B. Rumberger; T. Sparna; A. Schmitt-Graff; J. Wilpert; J. Timmer; G. Walz; H. L. Pahl (2005) Gene expression profiling in polycythaemia vera: overexpression of transcription factor NF-E2 Br J Haematol 129, 138-50.
M. Kottgen; T. Benzing; T. Simmen; R. Tauber; B. Buchholz; S. Feliciangeli; T. B. Huber; B. Schermer; A. Kramer-Zucker; K. Hopker; K. C. Simmen; C. C. Tschucke; R. Sandford; E. Kim; G. Thomas; G. Walz (2005) Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation EMBO J 24, 705-16.
B. Buchholz; R. Tauber; D. Steffl; G. Walz; M. Kottgen (2004) An inwardly rectifying whole cell current induced by Gq-coupled receptors Biochem Biophys Res Commun 322, 177-85.
F. Jochimsen; W. Gruening; T. Arnould; M. S. Segal; M. S. Kruskall; R. Colgrove, Jr.; G. Walz (2004) Thrombotic microangiopathy associated with unusual viral sequences in HIV-1-positive patients Nephrol Dial Transplant 19, 1129-35.
T. B. Huber; M. Simons; B. Hartleben; L. Sernetz; M. Schmidts; E. Gundlach; M. A. Saleem; G. Walz; T. Benzing (2003) Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains Hum Mol Genet 12, 3397-405.
G. Walz (2003) [Pathogenetic aspectics of nephrotic syndrome] Internist (Berl) 44, 1075-82.
J. Donauer; B. Rumberger; M. Klein; D. Faller; J. Wilpert; T. Sparna; G. Schieren; R. Rohrbach; P. Dern; J. Timmer; P. Pisarski; G. Kirste; G. Walz (2003) Expression profiling on chronically rejected transplant kidneys Transplantation 76, 539-47.
E. A. Otto; B. Schermer; T. Obara; J. F. O'Toole; K. S. Hiller; A. M. Mueller; R. G. Ruf; J. Hoefele; F. Beekmann; D. Landau; J. W. Foreman; J. A. Goodship; T. Strachan; A. Kispert; M. T. Wolf; M. F. Gagnadoux; H. Nivet; C. Antignac; G. Walz; I. A. Drummond; T. Benzing; F. Hildebrandt (2003) Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination Nat Genet 34, 413-20.
H. Olbrich; M. Fliegauf; J. Hoefele; A. Kispert; E. Otto; A. Volz; M. T. Wolf; G. Sasmaz; U. Trauer; R. Reinhardt; R. Sudbrak; C. Antignac; N. Gretz; G. Walz; B. Schermer; T. Benzing; F. Hildebrandt; H. Omran (2003) Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis Nat Genet 34, 455-9.
T. B. Huber; B. Hartleben; J. Kim; M. Schmidts; B. Schermer; A. Keil; L. Egger; R. L. Lecha; C. Borner; H. Pavenstadt; A. S. Shaw; G. Walz; T. Benzing (2003) Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling Mol Cell Biol 23, 4917-28.
P. Gerke; T. B. Huber; L. Sellin; T. Benzing; G. Walz (2003) Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1 J Am Soc Nephrol 14, 918-26.
T. B. Huber; M. Schmidts; P. Gerke; B. Schermer; A. Zahn; B. Hartleben; L. Sellin; G. Walz; T. Benzing (2003) The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1 J Biol Chem 278, 13417-21.
L. Sellin; T. B. Huber; P. Gerke; I. Quack; H. Pavenstadt; G. Walz (2003) NEPH1 defines a novel family of podocin interacting proteins FASEB J 17, 115-7.
G. Walz (2002) [Pathogenesis of cystic kidney diseases] Verh Dtsch Ges Pathol 86, 138-44.
T. Benzing; M. Kottgen; M. Johnson; B. Schermer; H. Zentgraf; G. Walz; E. Kim (2002) Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha J Biol Chem 277, 32954-62.
C. Nickel; T. Benzing; L. Sellin; P. Gerke; A. Karihaloo; Z. X. Liu; L. G. Cantley; G. Walz (2002) The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells J Clin Invest 109, 481-9.
T. B. Huber; M. Kottgen; B. Schilling; G. Walz; T. Benzing (2001) Interaction with podocin facilitates nephrin signaling J Biol Chem 276, 41543-6.
T. Benzing; P. Gerke; K. Hopker; F. Hildebrandt; E. Kim; G. Walz (2001) Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2 Proc Natl Acad Sci U S A 98, 9784-9.
R. Schreiber; P. Kindle; T. Benzing; G. Walz; K. Kunzelmann (2001) Control of the cystic fibrosis transmembrane conductance regulator by alphaG(i) and RGS proteins Biochem Biophys Res Commun 281, 917-23.
D. H. Vandorpe; M. N. Chernova; L. Jiang; L. K. Sellin; S. Wilhelm; A. K. Stuart-Tilley; G. Walz; S. L. Alper (2001) The cytoplasmic C-terminal fragment of polycystin-1 regulates a Ca2+-permeable cation channel J Biol Chem 276, 4093-101.
L. M. Guay-Woodford; C. J. Wright; G. Walz; G. A. Churchill (2000) Quantitative trait loci modulate renal cystic disease severity in the mouse bpk model J Am Soc Nephrol 11, 1253-60.
T. Benzing; M. B. Yaffe; T. Arnould; L. Sellin; B. Schermer; B. Schilling; R. Schreiber; K. Kunzelmann; G. G. Leparc; E. Kim; G. Walz (2000) 14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity J Biol Chem 275, 28167-72.
T. Benzing; R. Brandes; L. Sellin; B. Schermer; S. Lecker; G. Walz; E. Kim (1999) Upregulation of RGS7 may contribute to tumor necrosis factor-induced changes in central nervous function Nat Med 5, 913-8.
E. Kim; T. Arnould; L. Sellin; T. Benzing; N. Comella; O. Kocher; L. Tsiokas; V. P. Sukhatme; G. Walz (1999) Interaction between RGS7 and polycystin Proc Natl Acad Sci U S A 96, 6371-6.
S. Ananth; B. Knebelmann; W. Gruning; M. Dhanabal; G. Walz; I. E. Stillman; V. P. Sukhatme (1999) Transforming growth factor beta1 is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell renal carcinoma Cancer Res 59, 2210-6.
T. Arnould; L. Sellin; T. Benzing; L. Tsiokas; H. T. Cohen; E. Kim; G. Walz (1999) Cellular activation triggered by the autosomal dominant polycystic kidney disease gene product PKD2 Mol Cell Biol 19, 3423-34.
W. Gruning; T. Arnould; F. Jochimsen; L. Sellin; S. Ananth; E. Kim; G. Walz (1999) Modulation of renal tubular cell function by RGS3 Am J Physiol 276, F535-43.
L. Tsiokas; T. Arnould; C. Zhu; E. Kim; G. Walz; V. P. Sukhatme (1999) Specific association of the gene product of PKD2 with the TRPC1 channel Proc Natl Acad Sci U S A 96, 3934-9.
E. Kim; T. Arnould; L. K. Sellin; T. Benzing; M. J. Fan; W. Gruning; S. Y. Sokol; I. Drummond; G. Walz (1999) The polycystic kidney disease 1 gene product modulates Wnt signaling J Biol Chem 274, 4947-53.
M. J. Fan; W. Gruning; G. Walz; S. Y. Sokol (1998) Wnt signaling and transcriptional control of Siamois in Xenopus embryos Proc Natl Acad Sci U S A 95, 5626-31.
T. Arnould; E. Kim; L. Tsiokas; F. Jochimsen; W. Gruning; J. D. Chang; G. Walz (1998) The polycystic kidney disease 1 gene product mediates protein kinase C alpha-dependent and c-Jun N-terminal kinase-dependent activation of the transcription factor AP-1 J Biol Chem 273, 6013-8.
L. Tsiokas; E. Kim; T. Arnould; V. P. Sukhatme; G. Walz (1997) Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2 Proc Natl Acad Sci U S A 94, 6965-70.
H. Haller; U. Kunzendorf; K. Sacherer; C. Lindschau; G. Walz; A. Distler; F. C. Luft (1997) T cell adhesion to P-selectin induces tyrosine phosphorylation of pp125 focal adhesion kinase and other substrates J Immunol 158, 1061-7.
U. Kunzendorf; T. Pohl; S. Bulfone-Paus; H. Krause; M. Notter; A. Onu; G. Walz; T. Diamantstein (1996) Suppression of cell-mediated and humoral immune responses by an interleukin-2-immunoglobulin fusion protein in mice J Clin Invest 97, 1204-10.
U. Kunzendorf; S. Kruger-Krasagakes; M. Notter; H. Hock; G. Walz; T. Diamantstein (1994) A sialyl-Le(x)-negative melanoma cell line binds to E-selectin but not to P-selectin Cancer Res 54, 1109-12.
U. Kunzendorf; M. Notter; H. Hock; A. Distler; T. Diamantstein; G. Walz (1993) T cells bind to the endothelial adhesion molecule GMP-140 (P-selectin) Transplantation 56, 1213-7.
C. Stevens; G. Walz; C. Singaram; M. L. Lipman; B. Zanker; A. Muggia; D. Antonioli; M. A. Peppercorn; T. B. Strom (1992) Tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 expression in inflammatory bowel disease Dig Dis Sci 37, 818-26.
U. Kunzendorf; J. Brockmoller; U. Bickel; F. Jochimsen; G. Walz; I. Roots; G. Offermann (1991) Promotion of B cell stimulation in graft recipients through a mechanism distinct from interleukin-6 gene superinduction Transplantation 51, 1312-5.
U. Kunzendorf; G. Walz; J. Brockmoeller; H. H. Neumayer; F. Jochimsen; I. Roots; G. Offermann; T. B. Strom (1991) Effects of diltiazem upon metabolism and immunosuppressive action of cyclosporine in kidney graft recipients Transplantation 52, 280-4.
G. Walz; C. Stevens; B. Zanker; L. B. Melton; S. C. Clark; M. Suthanthiran; T. B. Strom (1991) The role of interleukin-6 in mitogenic T-cell activation: detection of interleukin-2 heteronuclear RNA by polymerase chain reaction Cell Immunol 134, 511-9.
A. Aruffo; W. Kolanus; G. Walz; P. Fredman; B. Seed (1991) CD62/P-selectin recognition of myeloid and tumor cell sulfatides Cell 67, 35-44.
P. K. Sehajpal; B. Li; B. Zanker; V. K. Murthi; A. Subramaniam; V. K. Sharma; D. Estin; E. Y. Skolnik; K. J. Wieder; G. Walz; et al. (1991) The molecular basis for the synergism between the CD3/alpha beta T cell receptor and the CD2 antigen-derived signals in promoting T-cell proliferation Transplantation 51, 468-74.
D. Camerini; G. Walz; W. A. Loenen; J. Borst; B. Seed (1991) The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family J Immunol 147, 3165-9.
G. Walz; B. Zanker; C. Barth; K. J. Wieder; S. C. Clark; T. B. Strom (1990) Transcriptional modulation of human IL-6 gene expression by verapamil J Immunol 144, 4242-8.
F. Keller; U. Kunzendorf; G. Walz; A. Schwarz; G. Offermann (1990) Slow accumulation of cyclosporin metabolites as measured by specific and nonspecific cyclosporin RIA Int J Clin Pharmacol Ther Toxicol 28, 167-75.
G. Walz; B. Zanker; J. R. Murphy; T. B. Strom (1990) A kinetic analysis of the effects of interleukin-2 diphtheria toxin fusion protein upon activated T cells Transplantation 49, 198-201.
B. Zanker; G. Walz; K. J. Wieder; T. B. Strom (1990) Evidence that glucocorticosteroids block expression of the human interleukin-6 gene by accessory cells Transplantation 49, 183-5.
G. Walz; U. Kunzendorf; O. Josimovic-Alasevic; L. Preuschoff; A. Schwarz; F. Keller; G. Asmus; G. Offermann; T. Diamantstein; A. Distler (1990) Soluble interleukin 2 receptor and tissue polypeptide antigen serum concentrations in end-stage renal failure Nephron 56, 157-61.
G. Walz; B. Zanker; L. B. Melton; M. Suthanthiran; T. B. Strom (1990) Possible association of the immunosuppressive and B cell lymphoma-promoting properties of cyclosporine Transplantation 49, 191-4.
K. J. Wieder; G. Walz; B. Zanker; P. Sehajpal; V. K. Sharma; E. Skolnik; T. B. Strom; M. Suthanthiran (1990) Physiologic signaling in normal human T-cells: mRNA phenotyping by northern blot analysis and reverse transcription-polymerase chain reaction Cell Immunol 128, 41-51.
G. Walz; A. Aruffo; W. Kolanus; M. Bevilacqua; B. Seed (1990) Recognition by ELAM-1 of the sialyl-Lex determinant on myeloid and tumor cells Science 250, 1132-5.
B. Zanker; G. Walz; K. J. Wieder; M. Moscovitch-Lopatin; B. R. Smith; T. B. Strom (1989) Verapamil selectively inhibits expression of interleukin-2 messenger RNA in mitogen activated mononuclear blood cells Transplant Proc 21, 85-7.
F. Keller; U. Kunzendorf; G. Walz; H. Haller; G. Offermann (1989) Saturable first-pass kinetics of propranolol J Clin Pharmacol 29, 240-5.
U. Kunzendorf; F. Keller; G. Walz; H. Haller; G. Offermann; K. Borner; H. Lode (1989) Multivariate analysis of aminoglycoside levels in hemodialysis patients Chemotherapy 35, 1-6.
U. Kunzendorf; J. Brockmoller; F. Jochimsen; F. Keller; I. Roots; G. Walz; G. Offermann (1989) Cyclosporin drug monitoring: comparison of four immunoassays and HPLC Klin Wochenschr 67, 438-41.
G. Walz; B. Zanker; K. Wieder; E. Hadro; M. Moscovitch-Lopatin; B. R. Smith; T. B. Strom (1989) Similar effects of cyclosporine and verapamil on lymphokine, interleukin 2 receptor, and proto-oncogene expression Transplantation 47, 331-4.
G. Walz; B. Zanker; K. Brand; C. Waters; F. Genbauffe; J. B. Zeldis; J. R. Murphy; T. B. Strom (1989) Sequential effects of interleukin 2-diphtheria toxin fusion protein on T-cell activation Proc Natl Acad Sci U S A 86, 9485-8.
G. Walz; U. Kunzendorf; H. Haller; F. Keller; G. Offermann; O. Josimovic-Alasevic; T. Diamantstein (1989) Factors influencing the response to hepatitis B vaccination of hemodialysis patients Nephron 51, 474-7.
G. Walz; U. Kunzendorf; A. Schwarz; R. Bauer; F. Keller; G. Offermann (1988) Elevated tissue polypeptide antigen as a risk factor for carpal tunnel syndrome in haemodialyzed patients Nephron 50, 83-4.
A. Schwarz; G. Walz (1988) [Beta 2 microglobulin. 2: Dialysis-associated amyloidosis] Fortschr Med 106, 334-7.
G. Walz; A. Schwarz (1988) [Beta 2 microglobulin. 1: Physiologic significance, behavior in kidney diseases and chronic hemodialysis] Fortschr Med 106, 331-3.
U. Kunzendorf; J. Brockmoller; F. Jochimsen; F. Keller; G. Walz; G. Offermann (1988) Cyclosporin metabolites and central-nervous-system toxicity Lancet 1, 1223.
G. Walz; U. Kunzendorf; F. Keller; R. Fitzner; G. Offermann (1988) Elevated tumor markers in hemodialysis patients Am J Nephrol 8, 187-9.
G. Walz; U. Kunzendorf; R. Bauer; F. Keller; G. Offermann (1988) The relevance of tissue polypeptide antigen (TPA) in patients with end-stage renal failure. Nieren- und Hochdruckkrankheiten 17, 211-214.
G. Walz; U. Kunzendorf; F. Keller; H. H. Neumayer; G. Offermann (1988) Cyclosporine blood levels in diltiazem-treated kidney graft recipients. Clin Transplantation 2, 21-25.
U. Kunzendorf; G. Walz; H. H. Neumayer; K. Wagner; F. Keller; G. Offermann (1987) Influence of diltiazem on blood cyclosporin levels Klin Wochenschr 65, 1101-3.
F. Keller; G. Walz; U. Kunzendorf; G. Offermann (1987) Initial pharmacokinetics and long-term dosage of cyclosporine. Nieren- und Hochdruckkrankheiten 16, 294-296.
Molecular and genetic basis of renal disease (edited by D. B. Mount and M. R. Pollak) Philadelphia: Saunders Elsevier. (0)
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