Publications

Hermle T, Simons M. (2023) ER stress and slit diaphragms: is there a connection? Kidney Int, doi: 10.1016/j.kint.2023.01.028.
Mathes N, Comas M, Bleul R, Everaert K, Hermle T, Wiekhorst F, Knittel P, Sperling RA, Vidal X. (2023) Nitrogen-vacancy center magnetic imaging of Fe3O4 nanoparticles inside the gastrointestinal tract of Drosophila melanogaster. Nanoscale Adv, doi: 10.1039/d3na00684k.
Gerstner L, Chen M, Kampf LL, Milosavljevic J, Lang K, Schneider R, Hildebrandt F, Helmstädter M, Walz G, Hermle T. (2022) Inhibition of endoplasmic reticulum stress signaling rescues cytotoxicity of human apolipoprotein-L1 risk variants in Drosophila. Kidney Int, doi: 10.1016/j.kint.2021.12.031.
Spitz D, Comas M, Gerstner L, Kayser S, Helmstädter M, Walz G, Hermle T. (2022) mTOR-Dependent Autophagy Regulates Slit Diaphragm Density in Podocyte-like Drosophila Nephrocytes. Cells, doi: 10.3390/cells11132103.
Lang K, Milosavljevic J, Heinkele H, Chen M, Gerstner L, Spitz D, Kayser S, Helmstädter M, Walz G, Köttgen M, Spracklen A, Poulton J, Hermle T. (2022) Selective endocytosis controls slit diaphragm maintenance and dynamics in Drosophila nephrocytes. Elife, doi: 10.7554/eLife.79037.
Milosavljevic J, Lempicki C, Lang K, Heinkele H, Kampf LL, Leroy C, Chen M, Gerstner L, Spitz D, Wang M, Knob AU, Kayser S, Helmstädter M, Walz G, Pollak MR, Hermle T. (2022) Nephrotic Syndrome Gene TBC1D8B Is Required for Endosomal Maturation and Nephrin Endocytosis in Drosophila. J Am Soc Nephrol, doi: 10.1681/ASN.2022030275.
Gebauer E, Bechtel-Walz W, Schell C, Erbel M, Walz G, Hermle T. (2021) Development of Nivolumab/Ipilimumab-Associated Autoimmune Nephritis during Steroid Therapy. Case Rep Nephrol Dial, doi: 10.1159/000517502.
Connaughton DM, Dai R, Owen DJ, Marquez J, Mann N, Graham-Paquin AL, ..., Hermle T, ..., Fisher SE, Bouchard M, Khokha MK, Shril S, Hildebrandt F. (2020) Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations Am J Hum Genet, doi: 10.1016/j.ajhg.2020.08.013.
Schneider R, Deutsch K, Hoeprich GJ, Marquez J, Hermle T, ..., Shril S, Khokha MK, Hoefele J, Goode BL, Hildebrandt F. (2020) DAAM2 Variants Cause Nephrotic Syndrome via Actin Dysregulation. Am J Hum Genet, doi: 10.1016/j.ajhg.2020.11.008.
Mao Y, Schneider R, van der Ven PFM, Assent M, Lohanadan K, Klämbt V, Buerger F, Kitzler TM, Deutsch K, Nakayama M, Majmundar AJ, Mann N, Hermle T, Onuchic-Whitford AC, Zhou W, Margam NN, Duncan R, Marquez J, Khokha M, Fathy HM, Kari JA, El Desoky S, Eid LA, Awad HS, Al-Saffar M, Mane S, Lifton RP, Fürst DO, Shril S, Hildebrandt F. (2020) Recessive Mutations in SYNPO2 as a Candidate of Monogenic Nephrotic Syndrome. Kidney Int Rep, doi: 10.1016/j.ekir.2020.10.040.
Kampf LL, Schneider R, Gerstner L, Thünauer R, Chen M, Helmstädter M, Amar A, Onuchic-Whitford AC, Loza Munarriz R, Berdeli A, Müller D, Schrezenmeier E, Budde K, Mane S, Laricchia KM, Rehm HL, MacArthur DG, Lifton RP, Walz G, Römer W, Bergmann C, Hildebrandt F and Hermle T. (2019) TBC1D8B Mutations Implicate RAB11-Dependent Vesicular Trafficking in the Pathogenesis of Nephrotic Syndrome J Am Soc Nephrol, doi: 10.1681/ASN.2019040414.
Teumer A, Li Y, Ghasemi S, Prins BP, Wuttke M, Hermle T, ..., Butterworth AS, Hung AM, Pattaro C and Köttgen A. (2019) Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria Nat Commun, doi: 10.1038/s41467-019-11576-0.
Kemming J, Reeves E, Nitschke K, Widmeier V, Emmerich F, Hermle T, Gostick E, Walker A, Timm J, Price DA, Hofmann M, Thimme R, James E and Neumann-Haefelin C. (2019) ERAP1 allotypes shape the epitope repertoire of virus-specific CD8+ T cell responses in acute hepatitis C virus infection J Hepatol, doi: 10.1016/j.jhep.2019.01.034.
Schapiro D, Daga A, Lawson JA, Majmundar AJ, Lovric S, Tan W, Warejko JK, Fessi I, Rao J, Airik M, Gee HY, Schneider R, Widmeier E, Hermle T, Ashraf S, Jobst-Schwan T, van der Ven AT, Nakayama M, Shril S, Braun DA and Hildebrandt F. (2019) Panel sequencing distinguishes monogenic forms of nephritis from nephrosis in children Nephrol Dial Transplant, doi: 10.1093/ndt/gfy050.
Braun DA, Warejko JK, Ashraf S, Tan W, Daga A, Schneider R, Hermle T, Jobst-Schwan T, Widmeier E, Majmundar AJ, Nakayama M, Schapiro D, Rao J, Schmidt JM, Hoogstraten CA, Hugo H, Bakkaloglu SA, Kari JA, El Desoky S, Daouk G, Mane S, Lifton RP, Shril S and Hildebrandt F. (2019) Genetic variants in the LAMA5 gene in pediatric nephrotic syndrome Nephrol Dial Transplant, doi: 10.1093/ndt/gfy028.
Braun DA, Lovric S, Schapiro D, ..., Hermle T, ..., Nürnberg P, Khokha MK and Hildebrandt F. (2018) Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome J Clin Invest, doi: 10.1172/JCI98688. Epub 2018 Sep 4.
van der Ven AT, Connaughton DM, Ityel H, ..., Hermle T, ..., Tasic V, Shril S and Hildebrandt F. (2018) Whole-Exome Sequencing Identifies Causative Mutations in Families with Congenital Anomalies of the Kidney and Urinary Tract J Am Soc Nephrol, doi: 10.1681/ASN.2017121265.
Braun DA, Shril S, Sinha A, Schneider R, Tan W, Ashraf S, Hermle T, Jobst-Schwan T, Widmeier E, Majmundar AJ, Daga A, Warejko JK, Nakayama M, Schapiro D, Chen J, Airik M, Rao J, Schmidt JM, Hoogstraten CA, Hugo H, Meena J, Lek M, Laricchia KM, Bagga A and Hildebrandt F. (2018) Mutations in WDR4 as a new cause of Galloway-Mowat syndrome Am J Med Genet A, doi: 10.1002/ajmg.a.40489.
Guida MC, Hermle T, Graham LA, Hauser V, Ryan M, Stevens TH and Simons M. (2018) ATP6AP2 functions as a V-ATPase assembly factor in the endoplasmic reticulum Mol Biol Cell, doi: 10.1091/mbc.E18-04-0234.
Hermle T, Schneider R, Schapiro D, ..., Lifton RP, Shril S and Hildebrandt F. (2018) GAPVD1 and ANKFY1 Mutations Implicate RAB5 Regulation in Nephrotic Syndrome J Am Soc Nephrol, doi: 10.1681/ASN.2017121312.
Ashraf S, Kudo H, Rao J, Kikuchi A, ..., Hermle T, ..., Zenker M, Kure S and Hildebrandt F. (2018) Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment Nat Commun, doi: 10.1038/s41467-018-04193-w.
Warejko JK, Tan W, Daga A, ..., Hermle T, ..., Lifton RP, Braun DA and Hildebrandt F. (2018) Whole Exome Sequencing of Patients with Steroid-Resistant Nephrotic Syndrome Clin J Am Soc Nephrol, doi: 10.2215/CJN.04120417.
Helmstädter M, Huber TB and Hermle T. (2017) Using the Drosophila Nephrocyte to Model Podocyte Function and Disease Front Pediatr, doi: 10.3389/fped.2017.00262.
Rao J, Ashraf S, Tan W, ..., Hermle T, ..., Khurana S, Martins JC and Hildebrandt F. (2017) Advillin acts upstream of phospholipase C epsilon1 in steroid-resistant nephrotic syndrome J Clin Invest, doi: 10.1172/JCI94138.
Braun DA, Rao J, Mollet G, ..., Hermle T, ..., Zenker M, Antignac C and Hildebrandt F. (2017) Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly Nat Genet, doi: 10.1038/ng.3933.
Hermle T, Braun DA, Helmstädter M, Huber TB and Hildebrandt F. (2017) Modeling Monogenic Human Nephrotic Syndrome in the Drosophila Garland Cell Nephrocyte J Am Soc Nephrol, doi: 10.1681/ASN.2016050517.
Braun DA, Sadowski CE, Kohl S, Lovric S, Astrinidis SA, Pabst WL, Gee HY, Ashraf S, Lawson JA, Shril S, Airik M, Tan W, Schapiro D, Rao J, Choi WI, Hermle T, Kemper MJ, Pohl M, Ozaltin F, Konrad M, Bogdanovic R, Büscher R, Helmchen U, Serdaroglu E, Lifton RP, Antonin W and Hildebrandt F. (2016) Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome Nat Genet, doi: 10.1038/ng.3512.
Gleixner EM, Canaud G, Hermle T, Guida MC, Kretz O, Helmstädter M, Huber TB, Eimer S, Terzi F and Simons M. (2014) V-ATPase/mTOR signaling regulates megalin-mediated apical endocytosis Cell Rep, doi: 10.1016/j.celrep.2014.05.035.
Hermle T, Guida MC, Beck S, Helmstädter S and Simons M. (2013) Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking EMBO J, doi: 10.1038/emboj.2012.323.
Hermle T, Petzoldt AG and Simons M. (2011) The role of proton transporters in epithelial Wnt signaling pathways Pediatr Nephrol, doi: 10.1007/s00467-011-1823-z.
Hermle T, Saltukoglu D, Grünewald J, Walz G and Simons M. (2010) Regulation of Frizzled-dependent planar polarity signaling by a V-ATPase subunit Curr Biol, doi: 10.1016/j.cub.2010.05.057.
Hermle T, Goestemeyer AK, Sweny P and Burns A. (2007) Successful therapeutic use of rituximab in refractory Wegener's granulomatosis after renal transplantation Clin Nephrol
Attanasio P, Shumilina E, Hermle T, Kiedaisch V, Lang PA, Huber SM, Wieder T and Lang F. (2007) Stimulation of eryptosis by anti-A IgG antibodies Cell Physiol Biochem
Kempe DS, Akel A, Lang PA, Hermle T, Biswas R, Muresanu J, Friedrich B, Dreischer P, Wolz C, Schumacher U, Peschel A, Götz F, Döring G, Wieder T, Gulbins E and Lang F. (2007) Suicidal erythrocyte death in sepsis J Mol Med (Berl)
Shumilina E, Kiedaisch V, Akkel A, Lang P, Hermle T, Kempe DS, Huber SM, Wieder T, Laufer S and Lang F. (2006) Stimulation of suicidal erythrocyte death by lipoxygenase inhibitor Bay-Y5884 Cell Physiol Biochem
Niemoeller OM, Akel A, Lang PA, Attanasio P, Kempe DS, Hermle T, Sobiesiak M, Wieder T and Lang F. (2006) Induction of eryptosis by cyclosporine Naunyn Schmiedebergs Arch Pharmacol
Hermle T, Shumilina E, Attanasio P, Akel A, Kempe DS, Lang PA, Podolski M, Gatz S, Bachmann R, Bachmann C, Abele H, Huber S, Wieder T and Lang F. (2006) Decreased cation channel activity and blunted channel-dependent eryptosis in neonatal erythrocytes Am J Physiol Cell Physiol
Lang PA, Beringer O, Nicolay JP, Amon O, Kempe DS, Hermle T, Attanasio P, Akel A, Schäfer R, Friedrich B, Risler T, Baur M, Olbricht CJ, Zimmerhackl LB, Zipfel PF, Wieder T and Lang F. (2006) Suicidal death of erythrocytes in recurrent hemolytic uremic syndrome J Mol Med (Berl)
Akel A, Hermle T, Niemoeller OM, Kempe DS, Lang PA, Attanasio P, Podolski M, Wieder T and Lang F. (2006) Stimulation of erythrocyte phosphatidylserine exposure by chlorpromazine Eur J Pharmacol
Lang PA, Kempe DS, Akel A, Klarl BA, Eisele K, Podolski M, Hermle T, Niemoeller OM, Attanasio P, Huber SM, Wieder T, Lang F and Duranton C. (2005) Inhibition of erythrocyte "apoptosis" by catecholamines Naunyn Schmiedebergs Arch Pharmacol
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UNI Freiburg Universitätsklinikum Freiburg DFG