Publications

Quatredeniers M, Bienaimé F, Ferri G, Isnard P, Porée E, Billot K, Birgy E, Mazloum M, Ceccarelli S, Silbermann F, Braeg S, Nguyen-Khoa T, Salomon R, Gubler MC, Kuehn EW, Saunier S, Viau A. (2022) The renal inflammatory network of nephronophthisis. Hum Mol Genet, Jan 19:ddac014. doi: 10.1093/hmg/ddac014.
Thuenauer R, Kühn K, Guo Y, Kotsis F, Xu M, Trefzer A, Altmann S, Wehrum S, Heshmatpour N, Faust B, Landi A, Diedrich B, Dengjel J, Kuehn EW, Imberty A, Römer W. (2022) The Lectin LecB Induces Patches with Basolateral Characteristics at the Apical Membrane to Promote Pseudomonas aeruginosa Host Cell Invasion. mBio, Jun 28;13(3):e0081922. doi: 10.1128/mbio.00819-22.
Pichler R, Rizzo L, Tröndle K, Bühler M, Brucker H, Müller AL, Grand K, Farè S, Viau A, Kaminski MM, Kuehn EW, Koch F, Zimmermann S, Koltay P, Lienkamp SS. (2022) Tuning the 3D microenvironment of reprogrammed tubule cells enhances biomimetic modeling of polycystic kidney disease. Biomaterials, Dec;291:121910. doi: 10.1016/j.biomaterials.2022.121910.
Peintner L, Venkatraman A, Waeldin A, Hofherr A, Busch T, Voronov A, Viau A, Kuehn EW, Köttgen M, Borner C. (2021) Loss of PKD1/polycystin-1 impairs lysosomal activity in a CAPN (calpain)-dependent manner. Autophagy, Sep;17(9):2384-2400. doi: 10.1080/15548627.2020.1826716.
Friedrich S, Müller H, Riesterer C, Schüller H, Friedrich K, Wörner CL, Busch T, Viau A, Kuehn EW, Köttgen M, Hofherr A. (2021) Identification of pathological transcription in autosomal dominant polycystic kidney disease epithelia. Sci Rep, Jul 23;11(1):15139. doi: 10.1038/s41598-021-94442-8.
Kotsis F, Janusch H, Li Y, Viau A, Epting D, Kramer-Zucker A, Walz G, Nitschke R, Lorentzen E, Ganner A, Neumann-Haefelin E, Kuehn EW, Boehlke C. (2021) Ift88, but not Kif3a, is required for establishment of the periciliary membrane compartment. Biochem Biophys Res Commun, Dec 20;584:19-25. doi: 10.1016/j.bbrc.2021.10.075.
Viau A, Kotsis F, Boehlke C, Braeg S, Klein M, Nitschke R, Walz G and Kuehn EW. (2020) Divergent function of polycystin 1 and polycystin 2 in cell size regulation Biochem Biophys Res Commun, Jan 8;521(2):290-295. doi: 10.1016/j.bbrc.2019.10.074.
Viau A, Baaziz M, Aka A, Mazloum M, Nguyen C, Kuehn EW, Terzi F, Bienaimé F. (2020) Tubular STAT3 Limits Renal Inflammation in Autosomal Dominant Polycystic Kidney Disease J Am Soc Nephrol, May;31(5):1035-1049. doi: 10.1681/ASN.2019090959.
Viau A, Bienaimé F, Lukas K, Todkar AP, Knoll M, Yakulov TA, Hofherr A, Kretz O, Helmstädter M, Reichardt W, Braeg S, Aschman T, Merkle A, Pfeifer D, Dumit VI, Gubler MC, Nitschke R, Huber TB, Terzi F, Dengjel J, Grahammer F, Köttgen M, Busch H, Boerries M, Walz G, Triantafyllopoulou A, Kuehn EW. (2018) Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney EMBO J, Jun 19. pii: e98615. doi: 10.15252/embj.201798615. [Epub ahead of print]
Hofherr A, Busch T, Huber N, Nold A, Bohn A, Viau A, Bienaimé F, Kuehn EW, Arnold SJ, Köttgen M. (2017) Efficient genome editing of differentiated renal epithelial cells Pflugers Arch., Feb;469(2):303-311. doi: 10.1007/s00424-016-1924-4. Epub 2016 Dec 16.
Orhon I, Dupont N, Zaidan M, Boitez V, Burtin M, Schmitt A, Capiod T, Viau A, Beau I, Kuehn EW, Friedlander G, Terzi F, Codogno P. (2016) Primary-cilium-dependent autophagy controls epithelial cell volume in response to fluid flow Nat Cell Biol., Jun;18(6):657-67. doi: 10.1038/ncb3360. Epub 2016 May 23.
Wolfgang Kühn and Gerd Walz (2016) The molecular basis of ciliopathies and cyst formation Oxford Textbook of Clinical Nephrology, 4th edition Oxford University Press, pp. 2597-2616
EW. Kuehn, G. Walz (2015) The Treatment of Autosomal Dominant Polycystic Kidney Disease Dtsch. Ärtzeblatt, Dec 21;112(51-52):884-90. doi: 10.3238/arztebl.2015.0884.
Wuttke M, Seidl M, Malinoc A, Prischl FC, Kuehn EW, Walz G, Köttgen A. (2015) A COL4A5 mutation with glomerular disease and signs of chronic thrombotic microangiopathy Clin Kidney J., Dec;8(6):690-4. doi: 10.1093/ckj/sfv091. Epub 2015 Sep 29. PMID: 26613025
C. Boehlke, H. Janusch, C. Hamann, C. Powelske, M. Mergen, H. Herbst, F. Kotsis, R. Nitschke, EW. Kuehn (2015) A Cilia Independent Role of Ift88/Polaris during Cell Migration PloS One 10, e0140378- e0140378
D. Epting, K. Slanchev, C. Boehlke, S. Hoff, N.T. Loges, T. Yasunaga, L. Indorf, S. Nestel, S.S. Lienkamp, H. Omran, E.W.Kuehn, O. Ronneberger, G. Walz, A. Kramer-Zucker. (2015) The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin Development 142 (1), 174-84.
M. Taschner, F. Kotsis, P. Braeuer, E.W. Kuehn, E. Lorentzen (2014) Crystal structures of IFT70/52 and IFT52/46 provide insight into intraflagellar transport B core complex assembly J Cell Biol 207(2), 269-82.
D. Li, E.W. Kuehn, R. Prekeris (2014) Kinesin-2 mediates apical endosome transport during epithelial lumen formation Cell Logist 4(1), e28928. Epub 2014 May 6.
K. Thedieck, B. Holzwarth, M. T. Prentzell, C. Boehlke, K. Klasener, S. Ruf, A. G. Sonntag, L. Maerz, S. N. Grellscheid, E. Kremmer, R. Nitschke, E. W. Kuehn, J. W. Jonker, A. K. Groen, M. Reth, M. N. Hall and R. Baumeister (2013) Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells Cell 154, 859-74.
S. Zschiedrich, E. P. Prager and E. W. Kuehn (2013) Successful treatment of the postpartum atypical hemolytic uremic syndrome with eculizumab Ann Intern Med 159, 76.
S. Hoff, J. Halbritter, D. Epting, V. Frank, T. M. Nguyen, J. van Reeuwijk, C. Boehlke, C. Schell, T. Yasunaga, M. Helmstadter, M. Mergen, E. Filhol, K. Boldt, N. Horn, M. Ueffing, E. A. Otto, T. Eisenberger, M. W. Elting, J. A. van Wijk, D. Bockenhauer, N. J. Sebire, S. Rittig, M. Vyberg, T. Ring, M. Pohl, L. Pape, T. J. Neuhaus, N. A. Elshakhs, S. J. Koon, P. C. Harris, F. Grahammer, T. B. Huber, E. W. Kuehn, A. Kramer-Zucker, H. J. Bolz, R. Roepman, S. Saunier, G. Walz, F. Hildebrandt, C. Bergmann and S. S. Lienkamp (2013) ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3 Nat Genet 45, 951-6.
C. Boehlke, F. Kotsis, B. Buchholz, C. Powelske, K. U. Eckardt, G. Walz, R. Nitschke and E. W. Kuehn (2013) Kif3a guides microtubular dynamics, migration and lumen formation of MDCK cells PLoS One 8, e62165.
F. Kotsis, C. Boehlke and E. W. Kuehn (2013) The ciliary flow sensor and polycystic kidney disease Nephrol Dial Transplant 28, 518-26.
T. B. Huber, G. Walz and E. W. Kuehn (2011) mTOR and rapamycin in the kidney: signaling and therapeutic implications beyond immunosuppression Kidney Int 79, 502-11.
S. Lienkamp; A. Ganner; C. Boehlke; T. Schmidt; S. J. Arnold; T. Schafer; D. Romaker; J. Schuler; S. Hoff; C. Powelske; A. Eifler; C. Kronig; A. Bullerkotte; R. Nitschke; E. W. Kuehn; E. Kim; H. Burkhardt; T. Brox; O. Ronneberger; J. Gloy; G. Walz (2010) Inversin relays Frizzled-8 signals to promote proximal pronephros development Proc Natl Acad Sci U S A 107, 20388-93.
C. Boehlke; F. Kotsis; V. Patel; S. Braeg; H. Voelker; S. Bredt; T. Beyer; H. Janusch; C. Hamann; M. Godel; K. Muller; M. Herbst; M. Hornung; M. Doerken; M. Kottgen; R. Nitschke; P. Igarashi; G. Walz; E. W. Kuehn (2010) Primary cilia regulate mTORC1 activity and cell size through Lkb1 Nat Cell Biol 12, 1115-22.
H. Schweizer; J. Boehm; J. T. Winterer; D. Wild; H. P. Neumann; T. Wiech; M. Stubanus; E. W. Kuehn (2010) Phaeochromocytoma and thrombotic microangiopathy: favourable outcome despite advanced renal failure J Clin Pathol 63, 754-6.
C. Boehlke; M. Bashkurov; A. Buescher; T. Krick; A. K. John; R. Nitschke; G. Walz; E. W. Kuehn (2010) Differential role of Rab proteins in ciliary trafficking: Rab23 regulates smoothened levels J Cell Sci 123, 1460-7.
H. Gao; Y. Wang; T. Wegierski; K. Skouloudaki; M. Putz; X. Fu; C. Engel; C. Boehlke; H. Peng; E. W. Kuehn; E. Kim; A. Kramer-Zucker; G. Walz (2010) PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation Hum Mol Genet 19, 16-24.
K. Skouloudaki; M. Puetz; M. Simons; J. R. Courbard; C. Boehlke; B. Hartleben; C. Engel; M. J. Moeller; C. Englert; F. Bollig; T. Schafer; H. Ramachandran; M. Mlodzik; T. B. Huber; E. W. Kuehn; E. Kim; A. Kramer-Zucker; G. Walz (2009) Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development Proc Natl Acad Sci U S A 106, 8579-84.
T. Wegierski; D. Steffl; C. Kopp; R. Tauber; B. Buchholz; R. Nitschke; E. W. Kuehn; G. Walz; M. Kottgen (2009) TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum EMBO J 28, 490-9.
M. Kottgen; B. Buchholz; M. A. Garcia-Gonzalez; F. Kotsis; X. Fu; M. Doerken; C. Boehlke; D. Steffl; R. Tauber; T. Wegierski; R. Nitschke; M. Suzuki; A. Kramer-Zucker; G. G. Germino; T. Watnick; J. Prenen; B. Nilius; E. W. Kuehn; G. Walz (2008) TRPP2 and TRPV4 form a polymodal sensory channel complex J Cell Biol 182, 437-47.
F. Kotsis; R. Nitschke; M. Doerken; G. Walz; E. W. Kuehn (2008) Flow modulates centriole movements in tubular epithelial cells Pflugers Arch 456, 1025-35.
E. W. Kuehn; M. N. Hirt; A. K. John; P. Muehlenhardt; C. Boehlke; M. Putz; A. G. Kramer-Zucker; M. Bashkurov; P. S. van de Weyer; F. Kotsis; G. Walz (2007) Kidney injury molecule 1 (Kim1) is a novel ciliary molecule and interactor of polycystin 2 Biochem Biophys Res Commun 364, 861-6.
D. Steffl, H. Gobel, C. Groth, K. G. Fischer, W. Kuhn, G. Walz and P. Gerke (2007) Quiz page. Renal AA amyloidosis with vascular predominance, secondary to rheumatoid arthritis Am J Kidney Dis 49, A49-50.
E. W. Kuehn; G. Walz; T. Benzing (2007) Von hippel-lindau: a tumor suppressor links microtubules to ciliogenesis and cancer development Cancer Res 67, 4537-40.
E. W. Kuehn; G. Walz (2007) Prime time for polycystic kidney disease: does one shot of roscovitine bring the cure? Nephrol Dial Transplant 22, 2133-5.
F. Kotsis; R. Nitschke; C. Boehlke; M. Bashkurov; G. Walz; E. W. Kuehn (2007) Ciliary calcium signaling is modulated by kidney injury molecule-1 (Kim1) Pflugers Arch 453, 819-29.
a. W. G. Kühn W (2007) Autosomal Dominante Polyzystische Nierenerkrankung Deutsches Ärzteblatt 104, A-3022-3028.
B. Schermer; C. Ghenoiu; M. Bartram; R. U. Muller; F. Kotsis; M. Hohne; W. Kuhn; M. Rapka; R. Nitschke; H. Zentgraf; M. Fliegauf; H. Omran; G. Walz; T. Benzing (2006) The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth J Cell Biol 175, 547-54.
P. S. van de Weyer; M. Muehlfeit; C. Klose; J. V. Bonventre; G. Walz; E. W. Kuehn (2006) A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9 Biochem Biophys Res Commun 351, 571-6.
E. W. Kuehn, K. M. Park, S. Somlo and J. V. Bonventre (2002) Kidney injury molecule-1 expression in murine polycystic kidney disease American journal of physiology. Renal physiology 283, F1326-36
W. Kuehn (2000) Michelangelo's gouty knee Lancet 355, 1104.
E. W. Kuehn, H. J. Anders, J. R. Bogner, J. Obermaier, F.D. Goebel and D. Schlondorff (1999) Hypocalcaemia in HIV infection and AIDS Journal of internal medicine 245, 69-73
J. Markovic-Lipkovski, C. A. Muller, G. Engler-Blum, F. Strutz, W. Kuhn, T. Risler, W. Lauchart and G. A. Muller (1992) Human cytomegalovirus in rejected kidney grafts; detection by polymerase chain reaction Nephrol Dial Transplant 7, 865-70.
G. A. Muller, C. A. Muller, G. Engler-Blum, W. Kuhn, T. Risler, A. Bohle and J. Markovic-Lipkovski (1992) Human cytomegalovirus in immunoglobulin A nephropathy: detection by polymerase chain reaction Nephron 62, 389-93.
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