Good and bad consequences of proximal tubular dysfunction: lessons from human genetics
How to form a mucociliary epithelium by actin-based pushing forces
We want to employ the Drosophila model to study mechanisms of genetic renal disease. Drosophila nephrocytes are functionally, morphologically and molecularly analogous to human podocytes. Unlike cultured cell lines, these podocyte-like cells form functional slit membranes reminiscent of the glomerular filter. We use the mature genetic tool-kit of the Drosophila model in conjunction with a functional and morphological analysis by fluorescent and electron microscopy. In order to discover novel therapies for nephrotic renal disease we apply specific protocols for whole organism drug screening.